Cascara Sagrada Bark Powder Extract 5% Hydroxyanthracen Glycosides

Frangula purshiana (cascara, cascara buckthorn, cascara sagrada, bearberry, and in the Chinook Jargon, chittem stick and chitticum stick; syn. Rhamnus purshiana) is a species of plant in the family Rhamnaceae. It is native to western North America from southern British Columbia south to central California, and eastward to northwestern Montana.The dried bark of cascara was used as a laxative in folk medicine by the indigenous peoples of the Pacific Northwest, and later worldwide in conventional medicines until 2002.Until 2002, cascara sagrada was the principal ingredient in commercial, over-the-counter (OTC) laxatives in North American pharmacies until the U.S. Food and Drug Administration (FDA) issued a final rule banning the use of aloe and cascara sagrada as laxative ingredients. Serious adverse effects may occur from using cascara, including dehydration, loss of electrolyte levels (such as potassium, sodium, chloride), heart rhythm irregularities, and muscle weakness. There is also concern for its potential carcinogenicity. Laxatives should also not be used by people with Crohn's disease, irritable bowel syndrome, colitis, hemorrhoids, appendicitis, or kidney problems. Use of cascara is a safety concern for pregnant or breastfeeding women, and for children.Cascara is sold in the United States as a dietary supplement and commonly ingested by mouth to relieve constipation. Although it may be safe for use over a few days, there is insufficient scientific evidence to assure its safety and effectiveness. Use of cascara may adversely affect the actions of various prescribed drugs, such as digoxin, warfarin, corticosteroids, and diuretic agents.